[A new technology for evaluating pharmacodynamics of antiaggregants].

The effect of antiaggregants on the system of regulation of the aggregative state of the whole blood in healthy volunteers has been studied using the global test of low-frequency piezothrombelastography. It is established that specific effects of antiaggregants are manifested in all stages of fibrinogenesis (initiation/amplification and propagation). According to the results of the global test at initial stages of hemocoagulation (initiation/amplification), a pronounced specific antiaggregative effect of COX-1 blockers and ADP receptors is accompanied by the intensification of thrombin activity and the formation of chronometric hypercoagulation.

[Effects of blood coagulating and fibrinolytic activity of tumor on the state of systemic hemostasis in patients with stomach cancer].

Functional status of hemostatic system was assessed in 75 gastric cancer patients and 40 healthy volunteers. Hemostatic potential of blood flowing off tumor was evaluated in 38 patients whereas fibrinolytic activity of tumor tissue samples--in 35. The results showed the degree and pattern of functional disorders occurring in the hemostatic system to depend upon the extent and procoagulant and fibrinolytic activity of tumor.

[Prevention of thromboembolic complications after surgical treatment of cancer of the stomach].

It was established that in patients with local spread of carcinoma of the stomach the hemostasis system makes danger of thrombogenesis due to lowered reserved possibilities of fibrinolysis and aggregation activity of the vessel wall. The state of danger of thrombogenesis under such conditions realizes itself in thrombi of profound veins of lower extremities detected by the method of radioisotope phlebography at the preoperative stage of treatment in 32.5% of the patients.