[Modern views on rheumatic fever].

Submitted in the paper are modern conceptions on etiology, pathophysiology, diagnosis and treatment of acute inflammatory rheumatism (IR). Some aspects of IR course in different age groups are highlighted, high informative value of new laboratory methods of diagnosis of its latent forms are validated. The place of interferons and selective inhibitors of COG-2 in the treatment of IR is determined.

[Antihomotoxic drug therapy of endothelial function disorder in patients with hypertension].

A multimodality therapy of patients with hypertensive disease involving the institution of basic conventional therapy and antihomotoxic preparations Hepar compositum and Ubichinon composition (Heel, Germany) has been shown to promote restoration of the degree of initial postischemic constriction but without normalization of responsiveness of vessels to the ischemic factor and nitroglycerin. Administration of antihomotoxic drugs exerted apparent optimizing effect on the state of the endothelial function that was manifested by returning parameters characterizing initial postischemic vasoconstriction and maximum postischemic vasodilatation to normal with high responsiveness to the endothelium-independent vasodilator nitroglycerin being maintained.

[Use of biotrof-3 in complex treatment of patients with postinfarct cardiosclerosis].

Results are submitted of clinical, instrumental, and laboratory methods of investigation in 50 patients with postinfarction cardiosclerosis before the start of the treatment and four weeks after conventional cardioactive therapy (control group) and the analogous therapy involving the use of a new biologically active home-produced drug preparation biotroph-3 in a complex therapy of patients with postinfarction cardiosclerosis permits shortening time for the general clinical improvement of the patients' state to be achieved due to apparent antiarrhythmic, antiischemic, and hypotensive effects along with reduction of manifestations of heart failure, as evidenced by the analysis of the results obtained.

[The characteristics of disorders of intracardiac hemodynamics and hemorheology in pulmonary heart failure].

Overall ninety patients with chronic obstructive bronchitis presenting with signs of varying degree cardiopulmonary insufficiency (CPI) were evaluated by radionuclide ventriculography with technetium pertechnetate as well as by rotational viscosimetry of blood. The degree of hemorheological derangements tended to get higher with CPI severity (light, moderately severe, severe) being accompanied by progressing impairement of systolic and diastolic functions of both ventricles of the heart. Mechanisms of compensation of endocardiac hemodynamics were realized as a result of increase in end-diastolic and end-systolic volumes of both ventricles together with changes in amplitude and time characteristics of processes of ventricular ejection and filling.

[The use of mildronate and trental in treating disorders of hemorheology and the intracardiac hemodynamics in patients with chronic obstructive bronchitis].

Overall ninety patients with chronic obstructive bronchitis presenting with signs of pulmonary-cardiac insufficiency (CPI) were studied by static radionuclide ventriculography with pertechnetate and rotation viscosimetry before and after a 14-day course of treatment. All the patients received basic treatment with cardiac glycosides on a differential basis depending upon CPI severity. Those patients having been prescribed mildronate additionally in a daily dose of 10 mg/kg body mass demonstrated improvement in left ventricular performance: the total and regional ejection fractions got increased, with the end-diastolic and end-systolic volumes having gotten reduced.