Proinflammatory mediators and reproductive failure in women with uterine fibroids.

Objective: study the levels of proinflammatory mediators and their correlation with reproductivefailure in women with uterine fibroids (UF).

Materials And Methods: 90 women aged 18 - 45 years (mean age - 33.9 ± 0.

[Congenital giant melanocytic nevi].

The paper describes a case of a rare tumor disease with massive involvement of the skin, mainly that of the occipital head and brain and liver tissues in a newborn infant. It considers the morphological and immunohistochemical characteristics of a giant tumor cell nidus in the skin of the occipital head.

Risk factors vary early preterm birth and perinatal complications after assisted reproductive technology.

We conducted a study of markers of endothelial dysfunction and angiogenesis regulation, as well as the identification of the main lymphocyte populations, activated CD3  CD95-cells and cytokine-producing CD4  IFN-γ-, CD4  IL-4-lymphocytes in the 1st trimester of gestation in women with ART-induced pregnancy and spontaneous pregnancy. We used the same indicators to assess the immune status of ELBW infants at birth and at the post-conceptual age of 38-40 weeks. It was determined that the risk factors of very early preterm delivery are: threatened miscarriage, chronic placental insufficiency, endothelial dysfunction, increased spontaneous production of intracellular cytokines.

Immunological and hemostasiological disorders in women with ovarian hyperstimulation syndrome.

To assess the markers of destabilization of homeostasis in women with ovarian hyperstimulation syndrome (OHSS), the investigation of the levels of cortisol, markers of renin-angiotensin-aldosterone system, endothelin, proinflammatory cytokines, acute phase proteins, and parameters of hemostasis was performed. Our survey involved 105 women who became pregnant after IVF: 21 women with symptoms of the early moderate and severe OHSS, 28 women with the late moderate and severe OHSS, and 56 pregnant women undergoing IVF without symptoms of OHSS. It was found significant increase of levels of cortisol, interleukins, the number of leucocytes, concentration of fibrinogen and D-dimers in patients with early and late OHSS.

[The evaluation of parameters of erythropoiesis and ferrokinetics in children born with extreme low body mass].

The article deals with the results of examination of 51 neonatal infants born with extreme low body mass in terms of gestation 22-31 week at first day of life and in 38-40 weeks of post conception age. The study established lowering of both values of indicators of erythrocyte sprout and level of iron-binding proteins in premature infants with extreme low body mass at birth and at achievement of age of mature infant.