Publications by authors named "I I Nazarov"

Background: The reduction of pulmonary congestion is an essential clinical target in the management of chronic heart failure. The remote dielectric sensing (ReDS) system is a recently introduced non-invasive technology used to easily estimate the degree of lung fluid volume without any expert techniques.

Objective: To conduct a comparative assessment of pulmonary congestion according to ultrasound and ReDS technology in patients hospitalized with decompensation of chronic heart failure (CHF).

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Mobile health has the potential to revolutionize health care delivery and patient engagement. In this work, we discuss how integrating Artificial Intelligence into digital health applications focused on supply chain operation, patient management, and capacity building, among other use cases, can improve the health system and public health performance. We present the Causal Foundry Artificial Intelligence and Reinforcement Learning platform, which allows the delivery of adaptive interventions whose impact can be optimized through experimentation and real-time monitoring.

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Metathesis homo- and copolymerization of bifunctional monomers bearing two norbornene moieties was studied. The monomers were synthesized from cis-5-norbornene-exo-2,3-dicarboxylic anhydride and various diamines (hexamethylenediamine, decamethylenediamine, 1R,3S-isophoronediamine). The metathesis homopolymerization of these bis(nadimides) in the presence of the second-generation Grubbs catalyst afforded glassy cross-linked polymers in more than 90% yields.

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Article Synopsis
  • BOB1 is a transcriptional coactivator that influences immune responses, autoimmunity, and blood cancers by affecting the DNA binding of OCT1 and OCT2.
  • The study used a method called EMSA-SELEX-Seq to explore how BOB1 changes DNA sequence preferences, confirming its selectivity for OCT1/2 dimers but also highlighting that monomeric forms are key targets.
  • These findings offer deeper insights into BOB1's role in immune regulation and its potential as a target for treating autoimmune diseases and blood cancers.
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Biogenic amines dopamine (DA) and serotonin (5-HT) are among the most significant monoaminergic neurotransmitters in the central nervous system (CNS). Separately, the physiological roles of DA and 5-HT have been studied in detail, and progress has been made in understanding their roles in normal and various pathological conditions (Parkinson's disease, schizophrenia, addiction, depression, etc.).

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