[Molecular genetic analysis of Y-chromosome micro deletions in men with severe spermatogenic defects].

Microdeletions of the Y-chromosomal AZF loci were revealed in 10 (12%) of 82 patients with severe idiopathic spermatogenetic defects. Deletions involved AZFc in six patients, AZFa in one patient, AZFb + c in two patients, and AZFa + b + c in one patient. Microdeletion analysis employed multiplex PCR with 22 pairs of primers directed to Y-specific STS of deletion intervals 5, 6, and 7 (Yq11).

[Effect of specific immunotherapy on the structural properties of the lymphocyte membranes in atopic diseases].

3-Methoxybenzathrone (MBA) fluorescence was used to explore the structural properties of blood lymphocyte membranes in patients with atopic bronchial asthma and pollenosis treated by specific immunotherapy. An analysis was made of the relationship between the changes in MBA fluorescence and the blood counts of T and B lymphocytes as well as the clinical efficacy of the treatment. As a result of the treatment, the patients manifested an appreciable increase in the MBA fluorescence intensity towards normal and higher limits, provided the results of the treatment were beneficial.