[Status of the thyroid gland in patients with schizophrenia].

A study was made of pituitary-thyroid function in patients with different forms of schizophrenia. Radioimmunoassay was used. All the patients with schizophrenia showed impairment of interrelations within the pituitary-thyroid system, which manifested by accumulation in the peripheral blood of metabolically active T3 due to enhanced degradation of T4 in the peripheral tissues.

[Amino acid reserves of the blood in patients with schizophrenia and their correction in insulin coma].

Free amino acid content was measured in the blood serum in patients with permanently progressive paranoid schizophrenia under conventional insulin shock therapy. The influence of several amino acids (methionine, glutamic acid) preinjection on their base levels was also assessed. Metabolic response to the insulin coma was different in preinjected vs.

[Middle-molecule spectrum of the blood serum in patients with a continuously progressive paranoid form of schizophrenia undergoing treatment].

Screening and gel filtration on Sephadex G-15 (Pharmacia, Sweden) were used to study mean molecular (MM) components (the level of total fraction and spectrum) in the serum of patients suffering from continuously progressing paranoid schizophrenia. The findings evidenced elevated level of the fraction and rearranged spectrum of the components. MM components 5 significant increase and peaks I decrease registered in the study may play a role in pathogenesis of the disease and underlie the development of its productive symptoms.

[Free amino acids and the total middle molecule fraction of the blood serum in patients with continuously progressive paranoid schizophrenia undergoing treatment].

The authors have investigated the levels of free amino acids and of the total fraction of medium molecules in the blood serum of patients with the paranoid form of continuously progressive schizophrenia. It has been demonstrated that these parameters are different in clinically normal individuals versus schizophrenics. The concentrations of free amino acids were the highest in people aged 40 to 50 years (Cys, Ala, Lys, Asp, Thr, Tyr, Try, Val, Leu, Ile) being considerably lower in individuals aged 50 to 60 years (Cys, Ala, Tyr) and over 60 years (Lys, His, Asp, Tyr, Try) which corresponds to the highest activity of the process in patients aged 40 to 50 years and its stabilization in older age.