Publications by authors named "I I Mathews"
Background: There is renewed interest in the use of ancient herbal remedies for their potential health benefits, particularly in the psychological domain. One herb that is receiving growing attention is lemon balm ( L.) which has received considerable interest for its influence on the brain.
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- Immune-related adverse events (irAEs) from immune checkpoint blockade (ICB) therapy affect many cancer patients, with their underlying causes not fully understood.
- Research identified a bio-active lipid called linoleoyl-lysophosphatidylcholine (LPC 18:2) that may play a key role in modulating these adverse events, with low levels of LPC 18:2 linked to the onset of severe irAEs.
- Supplementing LPC 18:2 in preclinical and human studies showed a reduction in harmful inflammation and neutrophil levels without detracting from the anti-tumor effectiveness of ICB therapy, suggesting it could enhance patient outcomes.
Mammalian transglutaminases, a family of Ca-dependent proteins, are implicated in a variety of diseases. For example, celiac disease (CeD) is an autoimmune disorder whose pathogenesis requires transglutaminase 2 (TG2) to deamidate select glutamine residues in diet-derived gluten peptides. Deamidation involves the formation of transient γ-glutamyl thioester intermediates.
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