Publications by authors named "I I Lomakin"
Article Synopsis
- Cryogenic electron microscopy (cryo-EM) and electron tomography allow researchers to see the structures of biological molecules in their true form at very high resolutions.
- Recent advancements in cryo-EM have made it usable in a wide range of health research due to improved methods and the establishment of dedicated research centers.
- The review discusses how single-particle cryo-EM is applied in dermatology research and includes examples of its potential in drug development.
Clindamycin: A Comprehensive Status Report with Emphasis on Use in Dermatology.
J Clin Aesthet Dermatol
August 2024
Article Synopsis
- * It can be applied topically or taken orally, with topical use being more prevalent due to concerns about antibiotic resistance and treatment efficacy.
- * The text reviews clindamycin's anti-inflammatory and antibiotic actions, pharmacokinetics, safety, and various applications beyond dermatology, emphasizing its therapeutic value.
Article Synopsis
- Inflammation and the anaerobic bacterium Cutibacterium acnes are key factors in acne development, making them primary targets for antibiotic treatments like tetracyclines, macrolides, and lincosamides.
- C. acnes has shown increasing resistance to these antibiotics, especially clindamycin, necessitating a deeper understanding of how these drugs interact with the bacteria.
- By determining the structure of clindamycin binding to the ribosome of C. acnes, the study reveals how this binding disrupts essential processes for protein synthesis, offering insights for overcoming antibiotic resistance and developing targeted treatments.
Obtaining comprehensive structural descriptions of macromolecules within their natural cellular context holds immense potential for understanding fundamental biology and improving health. Here, we present the landscape of protein synthesis inside human cells in unprecedented detail obtained using an approach which combines automated cryo-focused ion beam (FIB) milling and single-particle cryo-electron microscopy (cryo-EM). With this cryo-EM approach we resolved a 2.
View Article and Find Full Text PDF