Publications by authors named "I I Kats"
Paediatric medulloblastomas with chromothripsis are characterised by high genomic instability and are among the tumours with the worst prognosis. However, the molecular makeup and the determinants of the aggressiveness of chromothriptic medulloblastoma are not well understood. Here, we apply spatial transcriptomics to profile a cohort of 13 chromothriptic and non-chromothriptic medulloblastomas from the same molecular subgroup.
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- * The SpatialData framework offers a unified file format and lazy data representation, addressing issues like data volume and the need for flexible data structures.
- * SpatialData supports spatial annotations and cross-modal analysis, demonstrated through integrative analysis in a multimodal breast cancer study.
Article Synopsis
- The stability and turnover of proteins are influenced by their N-terminal sequences and how these sequences are processed, potentially leading to degradation signals.
- Researchers can gain insights into the effects of genetic changes on protein stability through methods that assess many N-terminal proteins at once, such as using tandem fluorescent timers (tFT).
- The protocol described allows for Multiplexed Protein Stability (MPS) profiling in yeast by sorting and analyzing large libraries of proteins with different N-termini, ultimately generating a stability index for each variant through deep sequencing.
The relationship between the human placenta-the extraembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-conductance vessels. Defects in trophoblast invasion and arterial transformation established during early pregnancy underlie common pregnancy disorders such as pre-eclampsia.
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