[Gilbert's syndrome: pathogenesis and diagnosis].

Pharmacological tests, dynamic hepatoscintigraphy, spectrophotometric evaluation of serum and bile content of bilirubin fractions were performed in examination of 136 patients with Gilbert syndrome (group 1), chronic hepatitis, steatosis or hepatic cirrhosis (group 2) and 23 patients free of hepatic pathology (control group). It was established that androgenic steroids have effect on bilirubin-glucuronidation. Hyperbilirubinemia in Gilbert syndrome can be caused not only inhibition of bilirubin-glucuronidation in the liver but also defective uptake of bilirubin by hepatocytes.

[Microstructure of vesicular agglomerates of the lithogenic bile].

Bimolecular layer of phospholipids and cholesterol is the structural base of the vesicular agglomerates of the lithogenic bile, as was shown by the methods of scanning and transmission electron microscopy. There are two morphologic versions of the lipid texture in agglomerates: a/multilayer's vesicles resembles to multilamellar liposomes b/aggregate of the bilayer's lamellae's growing in package. The authors considers that the lamellae's phase together with lipophilic and hydrophilic substances is not only predecessor, but also main structural component of the cholesterol bile stones.

[Characteristics of the microstructure of biliary calculi based on data from scanning electron microscopy].

Scanning electron microscopy was employed to study cholelithic microstructure. Irrespective of the chemical composition, the gall-stones demonstrated the presence of a cementing matrix composed of micellar-vesicular particles occurring either in aggregates or regularly spreading along the facets about the surface of crystalloid structures. There appeared to be a close relationship between the latter and the particles which are, viz.