[Different types of 199Tl chloride scintigraphic visualization of malignant tumors of the locomotor apparatus].

Background: 201Tl chloride scintigraphy allows malignant tumors of the locomotor apparatus to be diagnosed. The capacities of scintigraphy with 199Tl chloride, a 201Tl chloride analog, in addition to routine visualization of malignant tumors of the locomotor apparatus, have revealed its untypical variants.

Objective: to study the specific features of 199Tl chloride scintigraphic visualization of malignant tumor processes in the locomotor apparatus.

[Indices of proteolysis in evaluation of resorption in bone tumors].

Activities of acid and alkaline phosphatases, collagenase, cathepsin D, trypsin-like proteinases, alpha(1)-proteinase inhibitor (alpha(1)-PI), alpha(2)-macroglobulin (alpha(2)-MG) were measured in blood plasma and tumor tissue of patients with giant-cell tumor of the bone (GCTB) and bone chondrosarcoma. These tumors differed by enzymatic activities. GCTB is characterized by increased activity of alkaline phosphatase, while in chondrosarcoma tissue the activities of collagenase and cathepsin D were the highest.

[The comparative biochemical and morphological characteristics of chondrosarcoma and giant-cell tumor of the bone].

Spectrometry has been employed to assess the levels of collagenase, catepsin D, trypsin-like proteinases and their inhibitors as well as bone acid and alkaline phosphatase both in the center and along the periphery of giant cell tumor of bone (GCTB) and chondrosarcoma. The levels of collagenase, trypsin-like proteinases and their inhibitors in the center of chondrosarcoma were much higher while those of alkaline phosphatase--lower than along tumor periphery. The catepsin D and acid phosphatase concentrations of the center and periphery of chondrosarcoma were similar.

[The intraoperative irradiation of tumors].

Intraoperative irradiation of tumor was performed in 40 patients with cancer of the lung, stomach, breast, bone and soft tissues. It included irradiation of the bed of tumor removed. Fast electron beam was produced by a small betatron (collimator size--5 x 6 cm and 8 x 12 cm) installed in the operating room.

[Treatment tactics in giant cell tumor of the bone].

The data on 76 patients treated for benign or malignant giant-cell tumor (GCT) of the bone are presented. Surgery involving bone reconstruction and endoprosthetics was the basic therapeutic procedure. Cases with lytic benign GCT received 36-40 Gy of radiation prior to surgery whereas whose with malignant tumors were subjected to complex treatment including preoperative irradiation, surgery and chemotherapy.