[The effect of kryptopyrrole on the brain-activity of cats: a quantitative EEG-analysis (author's transl)].

Continuing earlier investigation Z. EEG-EMG, 1976, 7, 151-156 the authors have studied the electrical activity of the cortex and subcortical regions elicited by stimulating mesencephalic reticular formation, after injection i.p.

[The effects of kryptopyrrole on the brain of cats in the quantitative EEG-analysis (author's transl)].

A frequency analyzer and a biointegrator were used to study the effect of kryptopyrrole (20, 60 or 90 mg/kg) on the cortical and various subcortical structures in cat experiments. It was found that, as regards the subcortical structures, kryptopyrrole primarily causes significant bioelectric changes in the regions of the hippocampus and amygdala; its effects in the cortex are much less marked. In the second hour of the experiment, excitation appears in the behaviour of the cats, simultaneously with an increase in area of the slow frequency regions, where-as after 4-5 hours a considerable behaviour-inhibition can be observed simultaneously with a decrease in area of the slow wave range.

Effects of kryptopyrrole on porphyrin synthesis in Bacillus subtilis 168.

We investigated the effects of exogenous 5-aminolaevulinate and kryptopyrrole, separately and together, on the porphyrin synthesis of Bacillus subtilis 168. It was confirmed that 5-aminolaevulinate increases the porphyrin content of the culture fluid in the way previously described. In comparison with the basic activity of the bacteria, kryptopyrrole enhances the amount of extracellular copro III, uro III and 5-carboxyl porphyrins.