Publications by authors named "I Hovatta"
Importance: Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between AS and CAD.
Objective: To identify genetic risk loci and cardiovascular risk factors with AS-specific associations.
Background: Patients with Alzheimer's disease (AD) frequently present with cerebral amyloid angiopathy (CAA), characterized by the accumulation of beta-amyloid (Aβ) within the cerebral blood vessels, leading to cerebrovascular dysfunction. Pericytes, which wrap around vascular capillaries, are crucial for regulating cerebral blood flow, angiogenesis, and vessel stability. Despite the known impact of vascular dysfunction on the progression of neurodegenerative diseases, the specific role of pericytes in AD pathology remains to be elucidated.
View Article and Find Full Text PDFThe natural world is under unprecedented and accelerating pressure. Much work on understanding resilience to local and global environmental change has, so far, focussed on ecosystems. However, understanding a system's behaviour requires knowledge of its component parts and their interactions.
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- * A genome-wide association meta-analysis of nearly 122,000 ANX cases revealed 58 significant genetic variants and 66 related genes, with many of these findings replicated in a larger independent sample.
- * The findings indicate a substantial genetic overlap between ANX and other conditions like depression, emphasizing GABAergic signaling as a key mechanism, thereby enhancing our understanding of the genetic basis of ANX for future research.
Article Synopsis
- Evidence suggests that rapid-eye-movement sleep (REMS) plays a critical role in processing emotions, with systematic reviews focusing on the effects of REMS deprivation (REMSD).
- Animal studies show that longer REMSD leads to negative outcomes such as aggression, increased pain sensitivity, diminished sexual behavior, and impaired fear memory consolidation, while human studies mostly report effects after just one night of deprivation.
- There is a significant lack of research on the effects of chronic REMS suppression, especially considering the potential impact of medications like SSRIs, highlighting a gap in understanding its long-term consequences on emotional health.