Publications by authors named "I Houde"
Introduction: Novel approaches to improve long-term outcomes in kidney transplant recipients are required. Here, we present the 5-year data from a multicenter, prospective, Phase 3b trial evaluating treatment outcomes with standard (STD) or low (LOW) dose prolonged-release tacrolimus (TAC) combined with ACEi/ARB or other antihypertensive therapy (OAHT) in Canadian kidney transplant recipients.
Methods: Adult de novo kidney transplant recipients were randomized 2 × 2 to STD or LOW dose TAC and ACEi/ARB or OAHT.
Canadian Highly Sensitized Patient Program Report: A 1000 Kidney Transplants Story.
Can J Kidney Health Dis
December 2024
Purpose: Highly sensitized patients (HSPs) with kidney failure have limited access to kidney transplantation and poorer post-transplant outcomes. Prioritizing HSPs in kidney allocation systems and expanding the pool of deceased donors available to them has helped to reduce their wait times for transplant and enhanced post-transplant outcomes. The Canadian HSP Program was established by Canadian Blood Services in collaboration with provincial organ donation and transplantation programs throughout the country to increase transplant opportunities for transplant candidates needing very specific matches from deceased kidney donors.
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- * By analyzing blood samples from 118 kidney recipients over a median follow-up of 6.3 years, researchers developed a risk score based on age and immune cell responses, categorizing patients into low, intermediate, and high-risk groups for OIS.
- * The results showed that the risk score accurately reflected the likelihood of OIS events, with significant differences in risk percentages across the categories, highlighting the potential for improved personalized monitoring in organ transplant patients.
Introduction: De novo donor-specific HLA antibody (dnDSA) are associated with poor outcomes. Whether this observation applies to both HLA class I and II dnDSA remains unclear.
Methods: We studied 1236 consecutive kidney recipients who had routine anti-HLA antibody surveillance post-transplant.
Article Synopsis
- Interstitial fibrosis and tubular atrophy (IFTA) detected in kidney biopsies one year after transplantation is linked to poor graft outcomes, but how it evolves over time and its relationship with these outcomes is less clear.
- A study involving 248 adult kidney transplant recipients found that the progression of IFTA (ΔIFTA) was a significant risk factor for graft loss or increased serum creatinine levels.
- Key factors influencing ΔIFTA included recipient smoking status and donor diabetes, while donor age was predictive of initial IFTA but not its progression, highlighting the importance of understanding these dynamics for better transplant decisions.*