Publications by authors named "I Hirai"
Rosai-Dorfman disease presenting solely with intrathoracic lesions is exceptionally rare. Herein, we report the case of a 53-year-old man presenting with a posterior mediastinal tumour. Computed tomography revealed a 7-cm soft tissue shadow in the posterior mediastinum.
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- - The study investigates the effectiveness of trastuzumab and docetaxel chemotherapy for treating metastatic extramammary Paget's disease (EMPD), a rare cancer that shows similarities to breast cancer, particularly regarding HER2 expression.
- - Thirteen Japanese patients participated in this phase II trial, receiving the chemotherapy combination for up to two years, with a primary focus on measuring response rates and safety.
- - Results showed a high objective response rate of 76.9% after three cycles of treatment, with manageable side effects, suggesting that this combination therapy is a promising option for HER2-positive metastatic EMPD.
Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder affecting the palms and soles. In rare cases, severe patients develop acute extra-palmoplantar lesions often accompanied by arthralgia. Such cases with extensive symptoms often necessitate systemic treatments with variable efficacy and potential side effects.
View Article and Find Full Text PDFObjectives: Intraductal papillary mucinous neoplasm (IPMN) in individuals with at least one first-degree relative with IPMN is defined as familial IPMN. However, few studies have reported on familial IPMN, its clinical characteristics, or the associated genetic factors.
Materials And Methods: We report the case of a 58-year-old woman with multifocal IPMN and a mural nodule in the pancreatic body.