Publications by authors named "I Harada"
Protein tyrosine kinase 6 (PTK6), a non-receptor tyrosine kinase, is an oncogenic driver in many tumor types. However, agents that therapeutically target PTK6 are lacking. Although several PTK6 kinase inhibitors have been developed, none have been clinically translated, which may be due to kinase-independent functions that compromise their efficacy.
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- Extreme temperatures pose a significant threat to ectotherms like amphibians, particularly affecting their survival and development.
- The study focused on various populations of a "hot spring frog," examining their heat tolerance and development speed at different temperatures.
- Results indicated differences in heat tolerance among populations, with the Seranma hot spring group showing the highest survival and faster development, but all populations struggled to survive beyond 35°C, challenging earlier field observations.
The bromodomain and extra terminal (BET) family of bromodomain-containing proteins are important epigenetic regulators that elicit their effect through binding histone tail -acetyl lysine (KAc) post-translational modifications. Recognition of such markers has been implicated in a range of oncology and immune diseases and, as such, small-molecule inhibition of the BET family bromodomain-KAc protein-protein interaction has received significant interest as a therapeutic strategy, with several potential medicines under clinical evaluation. This work describes the structure- and property-based optimization of a ligand and lipophilic efficient pan-BET bromodomain inhibitor series to deliver candidate I-BET787 () that demonstrates efficacy in a mouse model of inflammation and suitable properties for both oral and intravenous (IV) administration.
View Article and Find Full Text PDFUnlabelled: Epithelial-mesenchymal transition (EMT) in cancer promotes metastasis and chemotherapy resistance. A subset of triple-negative breast cancer (TNBC) exhibits a mesenchymal gene signature that is associated with poor patient outcomes. We previously identified PTK6 tyrosine kinase as an oncogenic driver of EMT in a subset of TNBC.
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- The COVID-19 pandemic has led to a global rise in eating disorders, including in Japan, particularly among children under junior high school age.
- An online survey revealed that many pediatricians see an increase in visits for eating disorders, with about half of the respondents reporting a significant rise.
- Despite this increase, pediatricians face challenges in providing adequate psychotherapy and treatment, leading to overcrowding in psychiatric wards which affects the admission of children with other mental health issues.