Publications by authors named "I Hagege"
Objective: Frequency and titers of autoantibodies in patients with sickle-cell disease (SCD) have been reported as relatively high. In a prospective study of 88 patients, we examined this "hyper-autoreactivity" and its clinical consequences.
Methods: For 1 year, patients with SCD were screened for the presence in their serum of antinuclear, anti-double-stranded DNA, antiextractible nuclear antigens, anticardiolipin antibodies, and rheumatoid factors.
Background: beta-thalassemia is a rare disease in France, encountered mainly in patients originating from Italy and North Africa. In the setting of the recent French plan for rare diseases, a National Registry for thalassemia has been developed since 2005. Epidemiological and clinical data have been collected on living patients with beta-thalassemia major or intermedia, including those who underwent hematopoietic stem cell transplantation.
View Article and Find Full Text PDFBackground/aim: Hepatic complications are a major cause of death in patients with congenital anaemia and chronic hepatitis C. Ribavirin is usually contraindicated in patients with haemolytic anaemia. This pilot study evaluated the efficacy and safety of antiviral treatment in patients with sickle cell disease (SCD) or beta-thalassaemia major (TM).
View Article and Find Full Text PDFUrinary endothelin-1 as a marker of renal damage in sickle cell disease.
Nephrol Dial Transplant
November 2005
Article Synopsis
- Sickle cell disease (SCD) leads to kidney issues, including renal damage that heightens dehydration risk and promotes sickle crises due to factors like elevated endothelin-1 (ET-1) production.
- The study measured ET-1 levels in urine from asymptomatic SCD patients, revealing increased ET-1 compared to controls and significant links between urine ET-1 and kidney function defects.
- High ET-1 levels could cause nephrogenic diabetes insipidus and dehydration in SCD patients, suggesting potential benefits of using endothelin receptor antagonists to address kidney complications in this condition.