Publications by authors named "I H Son"
Background: Liver dysfunction has been reported as a risk factor for predicting complications after hepatectomy. In patients with liver cirrhosis (LC) who underwent hepatectomy, a Functional Liver Imaging Score (FLIS), derived from gadoxetic acid-enhanced magnetic resonance imaging (MRI), has never been investigated as a predictor of clinically significant post-hepatectomy complications.
Purpose: To evaluate whether FLIS can predict post-hepatectomy complications in patients with LC.
Artificial intelligence (AI)-based volumetric measurements for assessing sarcopenia are expected to offer comprehensive insight into three-dimensional muscle volume and distribution. Therefore, we investigated the role of sarcopenia using computed tomography (CT)-based automated AI volumetric muscle measurements in predicting neoadjuvant chemoradiotherapy (nCRT) response and prognosis in patients with rectal cancer who underwent nCRT. We retrospectively analyzed the data of patients who underwent nCRT followed by curative resection between March 2010 and August 2021.
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- Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein play significant roles in the development of Parkinson's disease, particularly through their impact on neuroinflammation and oxidative stress.
- In this study, a marine algal extract was found to inhibit LRRK2 activity, reduce inflammatory responses in microglial cells, and prevent α-synuclein fibril formation related to Parkinson's pathology.
- The extract also enhanced lysosomal function in human dopaminergic neurons and slightly improved cell survival in a model of oxidative stress induced by rotenone.
Article Synopsis
- The study investigates the effectiveness of using 3D-spheroids of human adipose stem cells (hASCs) for treating fecal incontinence by focusing on their ability to develop into smooth muscle cells (SMCs) when implanted in a mouse model.
- Researchers created a targeted model by freezing part of the internal anal sphincter (IAS) in rats and then analyzed SMC markers and related proteins after implanting either 3D-spheroids or 2D-cultured cells.
- Results showed that 3D-spheroids had greater expression of SMC markers and induced better contractile characteristics over time compared to 2D-hASCs, indicating a potential therapeutic benefit for fecal incontinence treatment.
Purpose: The COVID-19 pandemic has influenced various aspects of colorectal cancer (CRC) patient care, including diagnosis, treatment, and outcomes. This study assesses the pandemic's impact on CRC patients.
Methods: We performed a retrospective analysis of medical records for CRC patients who underwent surgery at five hospitals affiliated with Hallym University from January 2017 to December 2022.