Publications by authors named "I H Karahan"
Epidermal growth factor receptor (EGFR) mutations like the common L858R and exon 19 deletions are well studied, but rarer mutations like exon 19 insertions have received less attention. This case report describes a patient with this uncommon EGFR exon 19 insertion mutation in metastatic lung adenocarcinoma. A 51-year-old male nonsmoker with metastatic lung adenocarcinoma and a rare EGFR exon 19 insertion mutation experienced disease progression on initial carboplatin-pemetrexed chemotherapy.
View Article and Find Full Text PDFPurpose: Most bladder cancers are pure urothelial carcinomas, but a small portion, approximately 5-10%, have variant histology or are non-urothelial in nature. This research sought to examine the features of and treatment strategies for different types of urothelial carcinoma with variant histologies and non-urothelial bladder cancer.
Methods: The study cohort comprised individuals with non-urothelial and variant urothelial bladder cancers treated at two medical centres in Ankara, Turkey, between 2005 and 2024.
Article Synopsis
- Endometrium cancer is the most common gynecological cancer in developed countries, and this study was conducted to assess how HER2 positivity affects patient prognosis.
- The study analyzed 121 patients diagnosed with endometrial cancer between September 2019 and December 2023, categorizing them into HER2-low and HER2-high groups based on their HER2 immunohistochemistry scores.
- Findings showed that those in the HER2-high group had better survival outcomes than those in the HER2-low group, and both FIGO stage and HER2 status emerged as independent risk factors influencing overall survival.
IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the importance of the kinase function of IKKα in human physiology remains unknown since no biallelic variants disrupting its kinase activity have been reported. In this study, we present a homozygous germline missense variant in the kinase domain of IKKα, which is present in three children from two Turkish families.
View Article and Find Full Text PDFThe HALP score as a prognostic factor in metastatic biliary cancer.
Clin Transl Oncol
September 2024
Background: Biliary tract cancers are serious diseases and new biomarkers may be useful for the optimal management and prediction of these cases. This study aimed to evaluate the prognostic significance of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a novel composite marker, in patients with metastatic biliary tract cancer.
Methods: Patients with biliary tract cancers were analyzed retrospectively.