Synergistic suppression of cell growth: Phenmiazine derivatives targeting p53 and MDM2 unveiled through hybrid computational method.

Lung cancer is the leading cause of mortality in both men and women due to genetic and epigenetic modifications. Our study focuses on fabricating phenmiazine ring leads by a functional group-based drug design to inhibit p53 -7A1W and MDM2-7AU9 proteins responsible for cancer cell growth. One hundred molecules are designed and allowed to bind inside the active site of 7A1W and 7AU9 protein using a glide dock platform and subjected to find MMGBSA.

Investigating the toxicity of malachite green and copper sulfate in brine shrimp: and computational study.

Colour is crucial for enhancing the appetizing value and consumer acceptance of food products. The commonly used food colourants and food preservatives such as Malachite Green (MG) and Copper Sulfate (CS) can cause severe health problems. This study investigates the toxicity of these food-grade colourants through acute exposure using cytotoxicity using the brine shrimp model including 3D surface analysis (3DSA) and studies Brine shrimp were treated with various concentrations of MG and CS.

Effect of Silicone Rubber-Lead (SR-Pb) Thickness on Dose Reduction and Image Quality as Gonad Shield.

Background: Some organs in the body are sensitive to radiation such as eyes, breast, and gonads. Protection of sensitive organs against radiation is necessary. Recently, many sensitive organ shields have been developed from different materials.

[Comparative analysis of two surgical techniques for controlling nasal width after Le Fort I osteotomy].

Objective: To compare the efficacy of two surgical techniques for controllong nasal width after Le Fort I osteotomy.

Methods: Fifty-five patients who received the Le Fort I osteotomy have been included in this study. They were randomly divided into 2 groups.