Publications by authors named "I H Haralambieva"
Article Synopsis
- - Older adults (65+) often have weaker responses to flu vaccines, leading to the recommendation of special vaccines like MF59-adjuvanted (MF59Flu) and high-dose (HDFlu) vaccines for this age group in the U.S.
- - A study analyzed gene expression in CD4 T cells from 234 older vaccine recipients before and after vaccination, finding numerous differentially expressed genes (DEGs) that varied between MF59Flu and HDFlu recipients.
- - Interestingly, the identified DEGs did not significantly correlate with immune responses against the flu virus, indicating that other factors might be at play when it comes to flu immunity in older adults.
Article Synopsis
- T cell responses are crucial for measles immunity, helping in both antibody production and the elimination of infected cells.
- The study identified 13 measles-derived peptides that trigger immune responses in a mouse model, particularly focusing on four that showed strong immunogenicity.
- A vaccine using these four peptides significantly reduced illness and weight loss in mice after exposure to the measles virus, highlighting the potential for peptide-based vaccines.
B cell transcriptomic signatures hold promise for the early prediction of vaccine-induced humoral immunity and vaccine protective efficacy. We performed a longitudinal study in 232 healthy adult participants before/after a 3 dose of MMR (MMR3) vaccine. We assessed baseline and early transcriptional patterns in purified B cells and their association with measles-specific humoral immunity after MMR vaccination using two analytical methods ("per gene" linear models and joint analysis).
View Article and Find Full Text PDFVaccination against SARS-CoV-2 with coronavirus vaccines that elicit protective immune responses is critical to the prevention of severe disease and mortality associated with SARS-CoV-2 infection. Understanding the adaptive immune responses to SARS-CoV-2 infection and/or vaccination will continue to aid in the development of next-generation vaccines. Studies have shown the important role of SARS-CoV-2-specific antibodies for both disease resolution and prevention of COVID-19 serious sequelae following vaccination.
View Article and Find Full Text PDFThe responsiveness/cross-binding of vaccine-induced memory B cells/MBCs to previous and emerging divergent SARS-CoV-2 variants (e.g., Omicron) is understudied.
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