Publications by authors named "I H Fox"
As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the healthcare system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic (UPEC), while causes a significant portion of non-UPEC UTIs. Both bacteria express type 1 pili tipped with the mannose-binding FimH adhesin critical for UTI pathogenesis.
View Article and Find Full Text PDFObjectives: To investigate the barriers and facilitators to rehabilitation experienced by individuals with cervical SCI after upper limb (UL) reconstructive surgery.
Methods: We conducted a prospective cohort study with a follow-up period of up to 24 months. Data collection occurred at two academic and two Veterans Affairs medical centers in the United States.
Article Synopsis
- TM6SF2 rs58542926 (E167K) is linked to an increased risk of metabolic liver disease, prompting the need for a human model to study the mutation's effects due to conflicting animal study results.
- A human in vitro model was developed using gene editing on induced pluripotent stem cells, leading to observations of liver cell dysfunction, including lipid accumulation and reduced VLDL secretion associated with the mutation.
- The model demonstrated similarities to human conditions, facilitating future research on potential clinical interventions by addressing protein misfolding and ER stress related to the TM6SF2-E167K mutation.
Obesity and ovotoxicant exposures impair female reproductive health with greater ovotoxicity reported in obese relative to lean females. The mother and developing fetus are vulnerable to both during gestation. 7,12-dimethylbenz[a]anthracene (DMBA) is released during carbon combustion including from cigarettes, coal, fossil fuels, and forest fires.
View Article and Find Full Text PDFBackground: COVID-19 remains a global public health challenge due to new immune-evasive SARS-CoV-2 variants and heterogeneous immunity.
Methods: In this cross-sectional study, we evaluated the adaptive immune responses in US active duty personnel who completed a COVID-19 primary vaccine series and had heterogenous SARS-CoV-2 vaccination and infection histories to 3 previously dominant variants (ancestral, Delta, BA.5) and 3 circulating variants (XBB.