Publications by authors named "I H De Leeuw"
Lumpy skin disease virus (LSDV) is a vector-transmitted capripox virus that causes disease in cattle. flies are considered to be important vectors as they are able to transmit viruses from cattle with the typical LSDV skin nodules to naive cattle. No conclusive data are, however, available concerning the role of subclinically or preclinically infected cattle in virus transmission.
View Article and Find Full Text PDFThe current epidemic in Asia, driven by LSDV recombinants, poses difficulties to existing DIVA PCR tests, as these do not differentiate between homologous vaccine strains and the recombinant strains. We, therefore, developed and validated a new duplex real-time PCR capable of differentiating Neethling-based vaccine strains from classical and recombinant wild-type strains that are currently circulating in Asia. The DIVA potential of this new assay, seen in the in silico evaluation, was confirmed on samples from LSDV infected and vaccinated animals and on isolates of LSDV recombinants (n = 12), vaccine (n = 5), and classic wild-type strains (n = 6).
View Article and Find Full Text PDFVaccines have proven themselves as an efficient way to control and eradicate lumpy skin disease (LSD). In addition to the safety and efficacy aspects, it is important to know the duration for which the vaccines confer protective immunity, as this impacts the design of an efficient control and eradication program. We evaluated the duration of immunity induced by a live attenuated vaccine (LSDV LAV) and an inactivated vaccine (LSDV Inac), both based on LSDV.
View Article and Find Full Text PDFArticle Synopsis
- The vagus nerve is a key part of the parasympathetic nervous system, impacting many internal organs vital for health and measurable through heart-rate variability (HRV).
- Specific HRV metrics can indicate a lower risk of death, better recovery from heart issues, and improved cancer survival rates.
- HRV-biofeedback (HRV-B), a method involving slow-paced breathing and HRV visual feedback, shows promising results in treating conditions like coronary heart disease and hypertension, although evidence for its efficacy in diabetes and dementia remains limited.
Introduction: Head and neck cancer (HNC) and its treatment often negatively impact swallowing function. The aim was to investigate the course of patient-reported swallowing problems from diagnosis to 3, 6, 12, and 24 months after treatment, in relation to demographic, clinical, and lifestyle factors.
Methods: Data were used of the Netherlands Quality of Life and Biomedical Cohort Study in head and neck cancer research (NET-QUBIC).