Are gel blasters a safe toy? A study into their kinetic energy per unit area.

Gel blasters are currently imported and marketed as children's toys in Australia. Gel blasters closely imitate the appearance of many genuine firearms of all types and are designed to propel small hydrated gel balls of approximately 7-8 mm in diameter, by means of compressed air or gas. They are considered illegal in all states of Australia except Queensland but these items aren't specifically written into most state firearms legislation.

Nocardia species distribution and antimicrobial susceptibility within Australia.

Background: Nocardia is a ubiquitous saprophyte capable of causing human disease. Disease is primarily respiratory or cutaneous, usually acquired via inhalation or inoculation. Under the influence of environmental and host factors, Nocardia incidence and species distribution demonstrate geographical variation.

Multilocus Sequence Typing Reveals Extensive Genetic Diversity of the Emerging Fungal Pathogen .

spp. are the second most prevalent filamentous fungi after spp. recovered from cystic fibrosis (CF) patients in various regions of the world.

Radiation Augments the Local Anti-Tumor Effect of Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models.

Introduction: Combining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+OX40) is able to generate an effective vaccine in some tumor models, including the A20 lymphoma model. Immunologically "cold" tumors, which are typically less responsive to immunotherapy, are characterized by few tumor infiltrating lymphocytes (TILs), low mutation burden, and limited neoantigen expression. Radiation therapy (RT) can change the tumor microenvironment (TME) of an immunologically "cold" tumor.

Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade.

Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help prime and propagate antitumor immunity. We hypothesized that delivering radiation to all tumor sites could augment response to immunotherapies. We tested an approach to enhance response to immune checkpoint inhibitors (ICIs) by using targeted radionuclide therapy (TRT) to deliver radiation semiselectively to tumors.