[RADIOPROTECTIVE ACTIVITY OF POLYMETOXY-LATED FLAVONOIDS OF CITRUS EXTRACT].

The aim of the study was to establish the radioprotective activity of citrus polymetoxylated flavonoids extract (CPMFE) on the X-irradiated rats. The experiments were carried out on white Wistar rats. Animals were irradiated with X rays in doses of 5 Gy and 7 Gy.

[STUDY OF TOTAL ANTIOOCIDANT STATUS OF THE ORGANISM AS A POSSIBLE BIOMARKER OF DOSE AND EFFECT OF RADIATION EXPOSURE].

In presented article, by means of a comparative analysis of the relationship between the dose-dependent alterations in the organism's redox status, measured by the innovative method developed by us and the standard methods used for assessing catalase and superoxide dismutase activity, and an end radiobiological effect, was attempted the preliminary assessment of the possibility to apply the parameter of blood plasma total antioxidant activity (TAA) as marker of dose and effect of radiation exposure. The experiments were carried out on white mice randomly divided into groups of irradiated and sham irradiated animals. The mice were exposed to a whole body gamma irradiation by source Cesium-137 (137Cs) at doses of 5 and 7 Gr, a dose rate of 1.

Repetitive genomic sequences as a substrate for homologous integration in the Rhizopus oryzae genome.

The vast number of repetitive genomic elements was identified in the genome of Rhizopus oryzae. Such genomic repeats can be used as homologous regions for integration of plasmids. Here, we evaluated the use of two different repeats: the short (575 bp) rptZ, widely distributed (about 34 copies per genome) and the long (2053 bp) rptH, less prevalent (about 15 copies).

Is it possible to produce succinic acid at a low pH?

Bio-based succinate is still a matter of special emphasis in biotechnology and adjacent research areas. The vast majority of natural and engineered producers are bacterial strains that accumulate succinate under anaerobic conditions. Recently, we succeeded in obtaining an aerobic yeast strain capable of producing succinic acid at low pH.