Publications by authors named "I Grammatikakis"
Profiling Novel, Multifunctional Silane-Phosphonate Consolidants for the Mitigation of Gypsum Stone Deterioration via Concerted Autocondensation/Surface Complexation Processes.
Cryst Growth Des
July 2024
Mineral gypsum (selenite) stones have been used extensively by ancient Cretans in the Minoan Palace of Knossos (Crete, Greece), mostly for building and ornamental purposes. Exposure of mineral gypsum to environmental stresses (temperature fluctuations, rain, air-borne pollutants, soluble salts, etc.) causes solubility-driven degradation, and loss of cohesion of the crystal aggregates, with ensuing aesthetic degradation.
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- - Transcription factors, like Forkhead box A1 (FOXA1), are crucial for gene regulation in development and disease; FOXA1 is particularly important in cancer, acting as a pioneer factor and an oncogene while being reduced in colorectal cancer (CRC), suggesting it may have tumor-suppressing roles.
- - Research revealed that in CRC, FOXA1 mRNA is unstable, primarily due to its 3'UTR, and this instability is consistent across various CRC cell lines and patient organoids.
- - Staufen1 (STAU1) was identified as a key regulator of FOXA1; knocking down STAU1 led to increased FOXA1 mRNA stability and expression, highlighting a complex mechanism
Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone present on the endoplasmic reticulum (ER) membrane. S1R plays an important role in ER-mitochondrial inter-organelle calcium signaling and cell survival. S1R and its agonists confer resilience against various neurodegenerative diseases; however, the molecular mechanism of S1R is not yet fully understood.
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- Melanoma is the most aggressive skin cancer, known for spreading quickly and resisting treatments.
- Research shows that reactivation of certain developmental pathways in melanoma is linked to its onset and treatment challenges, with noncoding RNAs playing a key role.
- Understanding how noncoding RNAs function in melanoma could lead to new and improved therapies for this dangerous cancer.
Article Synopsis
- The study investigates the role of specific proteins (MMP-2, MMP-9, EGFR, and IL-8) in unexplained recurrent pregnancy loss (RPL) due to a lack of clear causes and treatments.
- It involves comparing tissue samples from 22 women with RPL and 18 women who opted for elective pregnancy termination, using immunohistochemical methods for analysis.
- Findings show significant differences in MMP-9, EGFR, and IL-8 levels between the two groups, suggesting that immune and structural abnormalities may contribute to RPL.