Maintenance treatment with budesonide 6 mg versus 9 mg once daily in patients with Crohn's disease in remission.

Background: In previous trials, budesonide 6 mg/day was able to prolong the time to relapse in patients with quiescent Crohn's disease and budesonide 9 mg/day was effective in active disease with limited side effects. The aim of this study was to compare the effectiveness of budesonide 9 mg vs 6 mg once daily on the maintenance of remission and occurrence of adverse events.

Methods: Double-blind, randomised trial in patients with Crohn's disease in remission.

Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect.

Background: Baroreflex sensitivity declines with age, creating a fall in systolic blood pressure and pulse pressure when standing. If, in addition, blood pressure is reduced as a result of antihypertensive medication, compensatory mechanisms may be inadequate and orthostatic problems may occur. This may be less true in patients on beta-blockers.