Publications by authors named "I Gorker"
Objectives: Autistic children frequently exhibit irritability, which can manifest as aggression, self-injurious behaviour, and severe tantrums, leading to significant impairments. Two atypical antipsychotics have been licensed by the Food and Drug Administration for the treatment of irritability in autistic children, although a significant percentage of these children do not respond to this treatment. This study aimed to determine the frequency of drug refractory irritability (DRI) and identify the risk factors in a large clinical sample of autistic children.
View Article and Find Full Text PDFInvestigation of Gene Variants in Non-Syndromic Autism Spectrum Disorder.
Noro Psikiyatr Ars
August 2024
Article Synopsis
- Genetic factors significantly influence autism spectrum disorder (ASD), with the POGZ gene being frequently mutated in affected individuals.
- The study evaluated the POGZ gene in 51 non-syndromic ASD cases and 50 control children, using advanced sequencing methods.
- Significant genetic variants were found in the ASD group that could impact brain development, suggesting a possible link to the disorder's etiology.
Background: Specific learning disorder (SLD) is a neurodevelopmental condition characterised by significant academic difficulties despite normal intelligence and adequate education. The difficulties with reading, writing, and arithmetic may manifest independently or concurrently at different ages. Early symptoms may appear in preschool, including delays in social skills, motor skills, and language development.
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- This study aimed to compare childhood-onset schizophrenia (COS) and early-onset schizophrenia (EOS) in terms of clinical characteristics, treatment approaches, and factors influencing prognosis.
- It involved analyzing data from 31 COS and 66 EOS patients, assessing their symptoms and treatment effectiveness using established scales during both acute and stable phases.
- Significant differences were found in treatment outcomes and symptom severity between the two groups, with COS patients showing higher comorbidities and requiring more complex treatments, highlighting the need for early diagnosis and specific predictors for better management of schizophrenia.
Background: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition typified by inattention, hyperactivity, and impulsivity. Comorbid psychiatric disorders are common among children and adolescents with ADHD. In this study, it was aimed to examine anxiety and somatic symptoms in children and adolescents with ADHD and the effect of methylphenidate treatment on these symptoms.
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