A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.

Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.

Interrelation of Stress, Eating Behavior, and Body Adiposity in Women with Obesity: Do Emotions Matter?

Background/objectives: Obesity is influenced by biological, hormonal, and social factors, contributing to chronic diseases and burdening the healthcare system. Chronic stress and emotional eating are linked to weight gain, affecting eating behaviors and metabolism. This study aimed to assess the association between stress, eating behavior, and adiposity in obese women.

Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis.

Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies.

Factors associated with nurses' search for training in auriculotherapy: a national cross-sectional study.

Objective: To analyze the sociodemographic profile and highlight factors associated with nurses' search for training in auriculotherapy.

Method: This is a cross-sectional study, with national scope, with 1,154 nurses. The data was collected digitally from June 2021 to January 2022 through a sociodemographic and training characterization questionnaire.

Pummelo fruit extract () reduces oxidative damage in peripheral blood of obese patients.

Objectives: To verify the level of oxidation of biomolecules in the peripheral blood of obese patients before and after incubation with the pummelo pulp extract at 25 mg/mL.

Methods: This investigation included 241 individuals, distributed across the following groups: control (n = 69; 30 men and 39 women); pre-obesity (n = 78; 29 men and 49 women); level I obesity (n = 62; 20 men and 42 women); and level II or III obesity (n = 32; 11 men and 21 women).

Results: TBARS and MN levels were significantly altered by incubation with pummelo extract in both genders and in all the groups according to their obesity level.