Publications by authors named "I Goldberg"
Background: Managing cancer associated thrombosis (CAT) is a significant clinical challenge due to several factors such as increased bleeding tendency, frailty, and drug - drug interactions. For many years, the drug of choice for treating CAT was low molecular weight heparin (LMWH); Recently, direct oral anticoagulants (DOACs) entered to the therapeutic milieu of CAT. However, due to the large diversity among patients with CAT in clinical and laboratory characteristics not all patients will equally benefit from treatment with DOACs.
View Article and Find Full Text PDFThe effect of increased triglycerides (TGs) as an independent factor in atherosclerosis development has been contentious, in part, because severe hypertriglyceridemia associates with low levels of low-density lipoprotein cholesterol (LDL-C). To test whether hyperchylomicronemia, in the absence of markedly reduced LDL-C levels, contributes to atherosclerosis, we created mice with induced whole-body lipoprotein lipase (LpL) deficiency combined with LDL receptor (LDLR) deficiency. On an atherogenic Western-type diet (WD), male and female mice with induced global LpL deficiency (i ) and LDLR knockdown ( ) developed hypertriglyceridemia and elevated cholesterol levels; all the increased cholesterol was in chylomicrons or large VLDL.
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- Immune checkpoint inhibitor (ICI) therapies used in cancer treatment may elevate the risk of heart-related issues in cancer survivors by worsening atherosclerosis, a condition affecting artery health.
- Researchers have identified a network of immune cell interactions within atherosclerotic plaques that can be targeted by ICIs, where a specific group of dendritic cells plays a significant role in immune signaling.
- The study also indicates that factors like type 2 diabetes and lipid-lowering medications can alter how immune cells interact, potentially affecting plaque inflammation and highlighting the need for strategies to reduce heart disease risk in patients undergoing ICI treatments.
Article Synopsis
- The study investigates how prenatal exposure to heavy metals (Lead, arsenic, cadmium, selenium) relates to adverse pregnancy outcomes, particularly focusing on differences between low-risk and high-risk groups of women with varying preterm birth histories.
- 404 women participated, and their blood metal levels were measured, showing significant differences in concentration between low-risk and high-risk groups, with low-risk having higher levels of these metals.
- Despite the findings of elevated metal levels, the study found no significant correlation between these metals and negative pregnancy outcomes, indicating a need for more research to explore the effects of these metals on pregnancy.