Efficacy and tolerability of piroxicam-beta-cyclodextrin in the outpatient management of chronic back pain.

Background: Piroxicam-beta-cyclodextrin (PBC) is the first nonsteroidal anti-inflammatory drug (NSAID), in which the active substance is complexed with the cyclic oligosaccharide cyclodextrin, which acts as an artificial receptor. This complex allows single molecules of the NSAID to be released adjacent to the gastrointestinal mucosa, instead of crystals. Since the piroxicam is immediately bioavailable in this formulation, the onset of action is similar to that of a parenteral drug.

[Intracerebral hemorrhage in hypertensives: diagnosis, therapy and prognosis].

The authors analyzed 98 cases of intracerebral haemorrhage in hypertonic subjects from the aspect of the clinical course, CT findings and therapeutic results. Thirty-seven patients were treated by surgery and 61 had medicamentous treatment. The acute mortality rate in operated patients was 57% in non-operated ones 30%.

Effects of a stable enkephalin analogue, (D-Met2,Pro5)-enkephalinamide, and naloxone on cortical blood flow and cerebral blood volume in experimental brain ischemia in anesthetized cats.

The effects of intracarotid injection of the stable enkephalin analogue (D-Met2,Pro5)-enkephalinamide (ENK) and intravenous administration of naloxone on the cerebrocortical blood flow (dye dilution method) and cerebral blood volume (CBV) (photoelectric method) were investigated during unilateral brain ischemia in anesthetized cats. Both parameters were measured simultaneously in the intact and ischemic (middle cerebral artery occluded) hemispheres. An intracarotid injection of ENK 0.