Comparative Virulence and Genomic Analysis of Isolates.

is a zoonotic bacterial swine pathogen causing substantial economic and health burdens to the pork industry. Mechanisms used by to colonize and cause disease remain unknown and vaccines and/or intervention strategies currently do not exist. Studies addressing virulence mechanisms used by have been complicated because different isolates can cause a spectrum of disease outcomes ranging from lethal systemic disease to asymptomatic carriage.

Refined mapping of quantitative trait loci for somatic cell score on BTA02 in the German Holstein.

The aim of this study was to more precisely map a previously reported quantitative trait locus (QTL) affecting somatic cell score on Bos taurus autosome 2 by increasing the number of markers fourfold, analysing more families and exploiting within-population linkage disequilibrium (LD). A granddaughter design of 10 German Holstein grandsire families with 1121 progeny tested sons was used. Twenty-six markers with an average marker spacing of 3.

Association between single nucleotide polymorphisms in the CXCR1 gene and somatic cell score in Holstein dairy cattle.

In addition to its position in a quantitative trait locus for somatic cell score (SCS) and its function in the immune response, the CXCR1 chemokine receptor gene located on Bos taurus autosome 2 is an auspicious candidate gene for udder health in dairy cattle. An association analysis was conducted in the German Holstein-Friesian population to test the association between the single nucleotide polymorphism (SNP) at position +777 within the CXCR1 gene and the SNP at position -1768 in the 5' upstream region of this gene (rs41255711) and the indicator trait SCS by using a grand-daughter design. Data were analyzed for 3 families, with a total of 749 genotyped bulls and an extended pedigree of 8,071 animals from the national German bovine genome mapping project.