Publications by authors named "I Godet"
The heterogeneity of epithelial-to-mesenchymal transition (EMT) programs is manifest in the diverse EMT-like phenotypes occurring during tumor progression. However, little is known about the mechanistic basis and functional role of specific forms of EMT in cancer. Here we address this question in lung adenocarcinoma (LUAD) cells that enter a dormancy period in response to TGF-β upon disseminating to distant sites.
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- Hypoxia, which is a lack of oxygen, happens in most solid tumors and can lead to cancer spreading and worse outcomes for patients.
- Breast cancer cells that are low in oxygen are much more likely to spread to the lungs in experiments with animals.
- By studying how these cancer cells behave, researchers found that blocking a specific protein called MUC1 can help stop the cancer from spreading and could lead to better treatments.
Mapping the Fate of Hypoxic Cells Using an Irreversible Fluorescent Switch.
Methods Mol Biol
February 2024
Hypoxia has been reported to promote tumor progression and metastasis in murine models, and patients with hypoxic tumors have a worse prognosis. Besides its effect on cancer, normal processes like embryogenesis, or other pathologies such as ischemia, depend on hypoxia-regulated mechanisms. Given the degradable nature of HIF-1/2α in the presence of oxygen, defining the role of hypoxia in modeling biological processes becomes challenging when a cell enters oxygen-rich regions within a tissue.
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- The paper presents a conceptual framework called "cell behavior hypothesis grammar," which translates biological knowledge into natural language statements to create computational models.
- This approach enables researchers to conduct virtual experiments that enhance understanding of complex multicellular systems, particularly in areas like tumor biology and immunotherapy, while fostering collaboration across various biological research fields.
Breast cancer is the most diagnosed cancer in women in the world. Mebendazole (MBZ) has been demonstrated to have preclinical efficacy across multiple cancers, including glioblastoma multiforme, medulloblastoma, colon, breast, pancreatic, and thyroid cancers. MBZ was also well tolerated in a recent phase I clinical trial of adults diagnosed with glioma.
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