Publications by authors named "I Gilron"

Purpose: While there is limited patient-centred evidence (i.e., evidence that is important for patients and end-users) to inform the use of pharmacologic opioid minimization strategies (i.

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Article Synopsis
  • Preclinical studies highlight the importance of glial cells in pain mechanisms, leading to a systematic review of human trials on glia-modulating drugs for pain treatment.
  • The review included 26 trials with a total of 2,132 participants, focusing on the effects of drugs like minocycline and pentoxifylline, but found significant variability among studies and no conclusive evidence of effectiveness.
  • Future research is encouraged to identify optimal glial-targeted drugs, the ideal timing and duration for their use, and improved designs for clinical trials to better assess their potential in pain management.
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Article Synopsis
  • Dexmedetomidine is being increasingly used in surgeries involving general anesthesia, but its impact on patient outcomes needs further evaluation.
  • A systematic review of 44 randomized controlled trials with nearly 5904 participants indicated that intraoperative dexmedetomidine significantly improved recovery quality after surgery.
  • The study found a 99% likelihood of any benefit from its use and an 88% chance of achieving a meaningful improvement in recovery, along with a reduction in chronic pain incidence.
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Background: Prescription opioid use places a considerable economic burden on health care systems. Older patients undergoing surgical procedures for painful conditions commonly receive opioids pre- and postoperatively, and are susceptible to adverse reactions. This study explores predictors of prolonged postoperative opioid use among older patients after lumbar spine surgery and the consequences in terms of health care utilization and costs.

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