Publications by authors named "I Gillespie"
A suspected anaphylactoid reaction to intravenous administration of mannitol in a dog.
J Vet Emerg Crit Care (San Antonio)
November 2024
Objective: To describe a case of a suspected anaphylactoid reaction to mannitol in a dog.
Case Summary: A 1-year-old, neutered female French Bulldog was anesthetized for a T12-T13 dorsal laminectomy surgery for a previously diagnosed spinal arachnoid diverticulum. Perioperatively, the spinal cord appeared grossly edematous, and IV mannitol administration was elected.
Article Synopsis
- Confounding by indication poses significant challenges in pharmacoepidemiology, particularly with time-varying confounders like infections affecting treatment and outcomes simultaneously.
- The paper introduces newly developed methods that incorporate active comparators in self-controlled study designs, specifically focusing on deriving active comparator rate ratios in self-controlled case series (SCCS).
- Through case studies on thiazolidinediones and fluoroquinolones, the authors compare different analytical approaches and provide guidelines to enhance the robustness of pharmacoepidemiological research.
Chronic hepatitis B (CHB) infection affects approximately 90 million people in China, where there are profoundly unmet clinical and public health needs. This study evaluated patient demographics, disease progression, and treatment management using national administrative claims data. This retrospective, observational study used anonymized data from the China Health Insurance Research Association claims database (January 1-December 31, 2016); data that could not be validated, or from duplicate entries, were excluded.
View Article and Find Full Text PDFObjectives: We set out to characterise chronic hepatitis B (CHB) in the primary care population in England and investigate risk factors for progression to hepatocellular carcinoma (HCC).
Study Design: Retrospective cohort study.
Methods: We identified 8039 individuals with CHB in individuals aged ≥18 years between 1999 and 2019 in the English primary care database QResearch.