Publications by authors named "I Garcia-Gorostiaga"
Introduction: Treatment with lithium can cause several neurological side effects, even at therapeutic levels.
Case Report: We report the case of a 49-year-old woman, with bipolar disorder and depression, undergoing treatment with lithium, antidepressants and antipsychotics, who was admitted to hospital due to a clinical picture of visual hallucinations with an elevated lithaemia of 2.1 mEq/L (therapeutic range: 0.
Objectives: To examine the efficacy of an integrative cognitive training program (REHACOP) to improve cognition, clinical symptoms, and functional disability of patients with Parkinson disease (PD).
Methods: Forty-two patients diagnosed with PD in Hoehn & Yahr stages 1 to 3 were randomly assigned to either the cognitive training group (REHACOP) or the control group (occupational activities) for 3 months (3 sessions, 60 min/wk). Primary outcomes were change on processing speed, verbal memory, visual memory, executive functioning, and theory of mind.
Article Synopsis
- The study compares nonmotor symptoms (NMS) in LRRK2-associated Parkinson's disease (LRRK2-PD) and idiopathic Parkinson's disease (IPD), emphasizing the differences in hyposmia between the two groups.
- Results showed that LRRK2-PD patients had better smell identification and lower hyposmia rates compared to IPD patients, with specific observations of gender differences in smell performance.
- Nonmotor symptoms like depression and sleep disturbances were found at similar rates in both groups, with over 40% of LRRK2-PD patients experiencing these symptoms before the onset of motor symptoms.
Memory deficits are common in persons with Parkinson's disease (PD) even without the presence of a frank dementia. These memory deficits have traditionally been attributed to inability of patients to retrieve information from long-term memory, referred to as the "retrieval failure hypothesis." However, some studies additionally document problems in recognition memory, noted to be inconsistent with the retrieval failure hypothesis.
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