Publications by authors named "I Gandolfini"
Article Synopsis
- * Despite the known association with complement activation, evidence shows that microvascular inflammation and endothelial damage can occur independently of this system, particularly in late AMR (>6 months post-transplant).
- * The review discusses differences in mechanisms and clinical features between early and late AMR, suggesting that treatment strategies should reflect these variations in underlying inflammatory processes and complement activation levels.
Article Synopsis
- Antibody-mediated rejection (AMR) is a major cause of long-term kidney transplant failure, even with advancements in immunosuppressive therapies.
- * A case is described where late active AMR progressed to severe chronic active AMR, treated with a multidrug approach.
- * The current treatment options and understanding of AMR, including the role of donor-specific antibodies and various therapeutic strategies, highlight a need for improved guidelines based on stronger evidence.*
Microvascular inflammation (MVI), defined as the presence of glomerulitis and/or peritubular capillaritis, is the key histological lesion of anti-HLA donor-specific antibodies (DSA)-related antibody mediated rejection, but recently other possible mechanisms of MVI have emerged. However, except for peritubular capillary C4d deposition that is more frequently observed in the presence of anti-HLA-DSA, histological features are similar regardless of MVI origin. Therefore, accurately describing patterns of MVI may help differentiate etiologies and drive therapeutic choices.
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