Publications by authors named "I Gallais-Serezal"
Article Synopsis
- Rituximab (RTX) is a key treatment for various autoimmune and chronic inflammatory diseases but increases the risk of severe infections and lowers vaccine effectiveness due to its impact on B cell responses.
- During the COVID-19 pandemic, RTX-treated patients faced heightened disease severity, which led to delays or avoidance of RTX treatments to protect against SARS-CoV-2 infections.
- A study of thirteen patients showed that while some had positive T cell responses post-vaccination, those recently treated with RTX had significantly lower antibody responses, suggesting a need for caution in timing vaccinations relative to RTX infusions to optimize immune protection.
Background: Vestibulodynia is a highly prevalent chronic pain disorder affecting the vulva having a major impact on women's physical, psychological, and sexual well-being. It remains an underrecognized disease that responds insufficiently to therapies such as physiotherapy and medication.
Aim: To assess the global efficacy of first-line therapies and factors associated with treatment escalation in women with vestibulodynia.
Perception and Experience of Dupilumab in Atopic Dermatitis: A Real-Life Study.
Patient Prefer Adherence
September 2023
Article Synopsis
- The study aimed to evaluate the experiences and perceptions of patients with atopic dermatitis (AD) regarding dupilumab treatment from January 2017 to December 2021.
- A total of 82 patients participated, with 77 completing a questionnaire on their treatment experience, including satisfaction levels and injection methods.
- The results indicated that dupilumab provided high patient satisfaction (mean score of 7.5) and a lower treatment burden, although 47% experienced a wearing-off of its beneficial effects.
Article Synopsis
- Relapses of psoriasis are linked to tissue-resident memory T cells that produce specific cytokines, which play a key role in maintaining inflammation in the skin.* -
- Research using gas chromatography/mass spectrometry shows that the fatty acid composition of skin differs between healthy individuals and normal-looking skin in psoriasis patients, yet there’s no significant difference between nonlesional and resolved skin.* -
- Higher levels of oleic acid in resolved skin correlate with a lower activation of IL-17 in T cells, suggesting that adjusting fatty acid levels could be a potential therapeutic strategy for managing inflammatory skin diseases.*