Publications by authors named "I Gallais"
Article Synopsis
- The study focuses on a pathogenic fungus and investigates its survival mechanisms, specifically the role of a transcription factor called PIG1 in the production of dihydroxynaphtalene (DHN)-melanin.
- By using CRISPR-Cas9 to create deletion mutants, researchers found that the absence of PIG1 hindered melanin production, resulting in a thinner and disorganized cell wall that decreased the fungus's ability to survive environmental stressors.
- The research highlights that PIG1 not only aids in melanin biosynthesis but may also play a crucial role in the fungus's overall virulence by helping it evade the host immune response.
Although originally described as transcriptional activator, SPI1/PU.1, a major player in haematopoiesis whose alterations are associated with haematological malignancies, has the ability to repress transcription. Here, we investigated the mechanisms underlying gene repression in the erythroid lineage, in which SPI1 exerts an oncogenic function by blocking differentiation.
View Article and Find Full Text PDFTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a well-known apoptosis inducer and a potential anticancer agent. When caspases and inhibitors of apoptosis proteins (IAPs) are inhibited, TRAIL induces necroptosis. Molecular mechanisms of necroptosis rely on kinase activation, and on the formation of a necrosome complex, bringing together the receptor-interacting protein kinases 1 and 3 (RIPK1, RIPK3), and the mixed lineage kinase domain-like protein (MLKL).
View Article and Find Full Text PDFLiver steatosis has been associated with various etiological factors (obesity, alcohol, environmental contaminants). How those factors work together to induce steatosis progression is still scarcely evaluated. Here, we tested whether phthalates could potentiate death of steatotic hepatocytes when combined with ethanol.
View Article and Find Full Text PDFA growing body of evidences indicate the major role of extracellular vesicles (EVs) as players of cell communication in the pathogenesis of liver diseases. EVs are membrane-enclosed vesicles released by cells into the extracellular environment. Oxidative stress is also a key component of liver disease pathogenesis, but no role for hepatocyte-derived EVs has yet been described in the development of this process.
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