ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING PROTEIN AND RISK OF MYOCARDIAL INFARCTION.

Objective: The aim: To study the association between A/A, G/A, A/A genotypes, alleles A, G of the SNP rs17216473 of the gene that encodes ALOX5AP and the risk of myocardial infarction within the Ukrainian population.

Patients And Methods: Materials and methods: PCR in real time and the analysis to discriminate alleles were used. The statistical processing was carried out by χ2 criteria and by χ2 criteria with Yates correction.

The study of leukocyte phagocytic activity in the presence of herpetic infection and stroke.

Objective: Inrtoduction: Post-stroke complications are one of the urgent and insufficiently resolved problems. According to different literature data 23% to 65% of patients suffer from the post-stroke development of an infectious process. Herpes simplex virus type 1 and 2 can also be etiological factors of stroke development, however their reactivation is seldom mentioned in clinical observations.

[The short-term effect of measured normobaric hypoxia on autonomic nervous system function in persons with hypo- and hyperacidic syndromes].

The functional activity of the vegetative nervous system was studied before and after the exposure to graded normobaric hypoxia having been realized as breathing with an artificial hypoxic mixture (AHM) during 10 to 40 minutes in subjects presenting with hypo- and hyperacidic syndromes. A relationship was established between activation of the sympathetic or parasympathetic regions and aggravation of the antecedent history (bad habits). It is suggested that a short-term AHM breathing be used as a test for preservation/failure of mechanisms of adaptation.

[The use of mountain air therapy for the correction of acid formation in patients with hypo- and hyperacidic syndromes].

Changes were studied in intragastric pH with the aid of micromethods of topo-pH-metry in 46 patients presenting with hypo- and hyperacidic syndrome exposed to artificial mountain air (AMA) therapy. The gas mixture containing 14% oxygen was formed by using molecular sieves. AMA was found out to have a significant sanogenic effect: it makes for acid production in patients with hypoacidic syndrome and reduces the above production in those patients presenting with hyperacidic syndrome AMA therapy administered along with the judicious employment of blockers, Hs-histamine receptors will, we believe, help in alleviating and dispelling the withdrawal syndrome.

[Restriction of two-replicon shuttle Escherichia coli-Streptomyces plasmids in Streptomyces lividans strain 66].

The shuttle Escherichia coli - Streptomyces plasmids were used to transform S. lividans 66. Plasmid DNAs isolated from this strain transform it 10-1000-fold more efficiently than DNAs from E.