[Mycotoxins: past, present and future].

The paper deals with historical information concerning the investigation of mycotoxins and mycotoxicoses at the Institute of Microbiology and Virology of the NAS of Ukraine, main results of the works fulfilled for the last 25 years and possible trends of further investigations.

[Changes in the composition of dendrochines in the cultivation dynamics of Dendrodochium toxicum 100115].

The dynamics of change in the component composition of dendrodochines in the process of cultivation of Dendrodochium toxicum 100115 has been studied. It has been shown on the basis of the data of thin-layer chromatography that verrucarines A and J are found during the whole period of the fungus growth. Rhoridines A and E in the initial period of cultivation (1-2 days) are found in trace quantities only.

[Verrucarin A from conidia of Dendrodochium toxicum Pidopl. et Bilai].

A substance which was dyed blue by 4p-(nitrobenzyl)pyridine, that evidenced for its trichotecene nature, has been isolated in the crystalline form from conidia Dendrodochium toxicum Pidopl. et Bilai--roridine H producer. Thin-layer chromatography of the substance in three different systems, the well-known macrocyclic trichotecenes being used as standards, permitted it to be identified with verrucarine A.

Comparative characteristics of some cultural and toxigenic properties of the Dendrodochium Bonorden and Myrothecium Tode ex Fr. representatives.

The comparative study of sporulation intensity, change of medium pH, yield of biomass and ethanol soluble fraction (ESF) of extracellular metabolites as well as antibiotic and toxigenic properties of 106 fungi strains which were the potential producers of macrocyclic trichothecenes has been carried out under the conditions of stationary cultivation. It was shown that all the studied Dendrodochium strains were characterized by moderate growth, variations of biomass were within 3.5-4.

[The antibiotic properties of the phytotoxic metabolites of Botrytis cinerea Pers].

Antibiotic properties of substances of a phytotoxic complex from Botrytis cinerea have been studied for a number of phytopathogenic bacteria, phytopathogenic and toxigenic fungi as well as saprophytic yeast strains. High fungistatic activity of preparations of phytotoxic metabolites (PTM) has been stated for Dendrodochium toxicum, Myrothecium verrucaria, M. roridum, Aspergillus fumigatus, Penicillium urticae, agents of heavy human and cattle mycotoxicoses.