[Morphofunctional status of the ovaries in patients with congenital adrenal cortical dysfunction].

The authors studied the morphofunctional state of the ovaries in 98 patients aged 15 to 40 with congenital adrenocortical dysfunction. It has been shown that primary amenorrhea and sterility observed in most of the patients were determined by changes in the ovaries and uterus as a result of a prolonged effect of androgens of adrenal origin. However these changes were reversible in nature because adequate glucocorticoid therapy is accompanied by the regeneration of ovarian function.

[Use of clomiphene in congenital adrenal cortical dysfunction].

The study of the functional state of the hypothalami-hypophyseal-ovarian system, using dexamethazone and clomiphene tests, has shown its ability to release gonadotropic hormones in response to stimulation and maintained relationship between the hypothalamus, hypophysis and ovaries in patients with congenital adrenocortical dysfunction. Further clomiphene administration was effective in patients, who suffered from congenital adrenocortical dysfunction with disturbed ovarian function, in spite of glucocorticoid treatment.

[Use of glucocorticoid preparations in congenital adrenocortical dysfunction].

Circadian changes in the corticosteroid, testosterone, and ACTH content in the blood plasma were examined to monitor the suppressant effect of glucocorticoids on adrenocortical and hypophyseal functions during administering glucocorticoid drugs to patients with congenital adrenocortical dysfunction. The daily dose of glucocorticoids was given in two intakes according to the two schemes: scheme 1 included the drug intake in the morning and in the afternoon, scheme 2 in the morning and in the evening. The effect of glucocorticoid therapy on the pattern of the circadian rhythm and the absolute corticosteroid and testosterone content was shown to depend on the time of the drug intake.

[Prolactin level in congenital adrenal cortex dysfunction].

Study of prolactin secretion in patients with congenital adrenal cortex dysfunction demonstrated that the majority of untreated patients displayed elevated blood prolactin content. Blood prolactin level fell after treatment with glucocorticosteroids. Blood prolactin level was elevated, irrespective of normal or increased 24-hour 17-CS excretion in patients with congenital adrenal gland dysfunction treated with glucocorticosteroids and with persistent disturbances of ovarian function.