Exploratory Study on Lercanidipine Hydrochloride Polymorphism: pH-Dependent Solubility Behavior and Simulation of its Impact on Pharmacokinetics.

This work describes an exploratory experimental and in silico study of the influence of polymorphism, particle size, and physiology on the pharmacokinetics of lercanidipine hydrochloride (LHC). Equilibrium and kinetic solubility studies were performed on LHC forms I and II, as a function of pH and buffer composition. GastroPlus® was used to evaluate the potential effect of solubility differences due to polymorphism, particle size, and physiological conditions, on the drug pharmacokinetics.

[The substantiation of the method of gastrointestinal reconstruction after the gastric resection].

Functional results of 289 major gastric resections and gastrectomies were analyzed. New methods of the gastrointestinal reconstruction after these procedures. The comparative analysis of immediate and long-term results allowed to work out criteria of choice for the reconstructive procedure.

[Diagnostics and surgical correction of postoperative myofascial defects of lateral abdominal wall and lumbar region].

Myofascial defects of lateral abdominal wall and lumbar region occur chiefly after lumbotomy--the most popular access in urosurgery. Meanwhile lumbotomy remains one of the most traumatic accesses through the lateral abdominal wall. Myofascial defects were diagnosed in 48,9% of operated patients with lumbotomy.

[Outcomes of surgical treatment of patients with progressive pulmonary tuberculosis an concomitant diseases].

The pattern of concomitant diseases has been studied in 708 patients operated on for progressive pulmonary tuberculosis. The incidence of concomitant diseases has been found to considerably increase in recent years and it was as high as 77%. Peptic ulcer and chronic viral hepatitis were responsible for 1.