[2-Methyl-3-phenylaminomethylquinolin-4-one as potential antidepressant with nootropic properties].

The new compound, 2-methyl-3-phenylaminomethylquinolin-4-on, belongs to V class of toxicity and exhibits antidepressant and antiamnesic properties. It is established that this compound reduces the duration of immobilization in the test of behavioral despair, prevents from the scopolamine induced amnesia, and exhibits antagonism with reserpine in mice. In a dose of 100 mg/kg, the synthesized compound influences the levels of cerebral catecholamines similarly to imipramine, but with a more pronounced decrease in the level of 5-hydroxytryptamine.

[Fullerenes C60, antiamyloid action, the brain and cognitive processes].

A short review of investigations along a new line: the antiamyloid action of fullerenes C60 and correction of disturbed cognitive processes is presented. The prospects for the development of drugs based on fullerenes acting on the key molecular mechanisms at the early stage of Alzheimer's disease are discussed.

[Central administration of the amyloid beta-peptide (25-35) and individual features of cognitive behavior of rats].

Individual features of cognitive behavior of rats induced by the administration of the aggregated amyloid beta3-peptide (25-35) (Abeta25-35) into the lateral ventricles of the brain were studied. A new approach to the estimation of individual differences in the effects of Abeta25-35 was applied. Navigation training was performed in one short session with a random position of a target; sessions were repeated with the intervals of a few days.

[Mechanism of eclamptic coma development].

Analysis of the course of the disease in 28 puerperas with eclamptic coma has ascertained that it develops only in the presence of hypokinetic circulation as a result of lower circulating blood volume and cardiac index, which is followed by a cerebral circulation reduction to the critical values due to blood flow in the cortical structures. To maintain high blood flow in the subcortical structures is one of the leading causes of vasogenic edema of brain glia, followed by impaired liquorodynamics, which indices eclampsia. Low sustained cerebral circulation as a consequence of inadequate intensive care favors the extent of edema to the cerebral cortical structures after relieving eclampsia.

[Biological systems of life support for space crews: some results and anticipations].

One of the challenges for space biology and medicine is resolution of lots of problems of biomedical support of humans in the extreme environment of space flight. These problems include also designing of robust and efficiently functioning life support systems (LSS). The paper gives an overview of the investigations of ground-based BLSS with human subjects conducted in Russia and other countries.