Publications by authors named "I G Motta"
Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. Glutamine synthetase (GS), one of the oldest functioning genes in evolution, is activated during erythroid maturation to detoxify ammonium generated from heme biosynthesis, which is up-regulated to support hemoglobin production.
View Article and Find Full Text PDFAnemia during acute inflammation is not well described in the literature. We aimed to study whether patients develop a transient hemoglobin decrease during an acute attack of recurrent pericarditis. We retrospectively analyzed patients with recurrent pericarditis.
View Article and Find Full Text PDFArticle Synopsis
- Anemia and hyperferritinemia are common at the onset of Gaucher disease, affecting 41% and 51% of patients respectively.
- Over a 5-year period, enzyme replacement therapy (ERT) significantly improved hemoglobin levels, decreased markers of ineffective erythropoiesis, and reduced serum ferritin, indicating better iron metabolism.
- The study highlights the important role of iron dysregulation in anemia for Gaucher disease patients and shows that ERT enhances both erythropoiesis and iron handling.