Publications by authors named "I G Morris"

Objectives: Intubation is a common procedure in acute hypoxemic respiratory failure (AHRF), with minimal evidence to guide decision-making. We conducted a survey of when to intubate patients with AHRF to measure the influence of clinical variables on intubation decision-making and quantify variability.

Design: Factorial vignette-based survey asking "Would you recommend intubation?" Respondents selected an ordinal recommendation from a 5-point scale ranging from "Definite no" to "Definite yes" for up to ten randomly allocated vignettes.

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Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with invariant NKT cells (iNKT cells), which in turn secrete various cytokines. A lipid-rich microenvironment, as observed in obesity, skews this adipocyte-driven cytokine output towards a more inflammatory output.

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  • - This study investigates how the medications propofol and fentanyl behave in the body (PK/PD) in patients using veno-venous extracorporeal membrane oxygenation (V-V ECMO) due to a lack of existing data in this area.
  • - Conducted at Toronto General Hospital ICU, the research involved 11 patients monitored over a median of 146 hours, revealing that both medications follow a two-compartment model for clearance and that over-sedation was common despite increased clearance rates shortly after ECMO began.
  • - Results show that while clearance of sedatives increased temporarily after ECMO initiation and differences were noted based on sex, sedation effectiveness varied and respiratory effort was inconsistent regardless of medication levels.
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  • Patients with hematological malignancies face high risks of serious complications, and this study aimed to assess how hyperoxemia (high levels of oxygen in the blood) impacts mortality rates within 28 days in critically ill individuals.
  • An analysis of data from over 11,000 patients revealed a U-shaped relationship between arterial oxygen levels (PaO) and mortality, indicating that both low and high oxygen levels can increase the risk of death.
  • The study found that excessive use of oxygen was significantly linked to increased mortality rates, especially in certain patient groups, highlighting the importance of careful oxygen management in these critically ill patients.
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  • The study examines the role of the pseudokinase Tribbles 3 (TRIB3) in energy metabolism by using Trib3 knockout mice to understand its effects on fat cells and overall metabolic health.
  • Results show that while Trib3 mice are fatter, their insulin sensitivity doesn't change, and their fat cells are smaller with increased proliferation markers, suggesting TRIB3 affects how these cells grow and store fat.
  • Overall, TRIB3 is implicated in various cellular processes through different signaling pathways, indicating it plays a crucial role in maintaining the health of fat tissue rather than just one specific function.
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