[Therapeutic effectiveness of acetylcysteine in acute dichloroethane poisoning].

With its multiple administration acetylcysteine is shown to display a marked curative effect in acute poisoning of animals (rats, mice, rabbits) with ethylene dichloride. It increases the survival of animals and largely prevents disorders in hemopoiesis and in the blood coagulation system, minimizing toxic lesions of the liver and kidneys.

[Effect of a new cholinesterase reactivator, diethixime, on the central nervous system].

A new cholinesteras reactivator--chlorohydrate of S-diethylaminoethyl ether p-bromo benzoylthiohydroxime acid (diethixime), containing a tertiary nitrogen atom in the molecule, was shown to produce a central effect in a dose of 20 mg/kg--1/50 LD50--in contrast to diproxime in a dose of 3 mg/kg, containing a quarternary nitrogen atom, under intoxication of albino rats and rabbits with dimethyl-dichlorynylphosphate. This effect was confirmed by the restortion of the cholinesterase activity in different parts of the rabbit brain, by the normalization of the EEGand of the functional stateof motor neurons of the rat spinal cord.