[The characteristics of left ventricular myocardial remodeling in patients with chronic renal disease, and the effects of spironolactone therapy].

The work reflects modern concepts of the pathogenesis of myocardial and vascular remodelling in a chronic renal disease. Types of changes in left ventricular geometry and the condition of the diastolic function in patients at pre-dialysis stage of a chronic renal disease and patients on program hemodialysis. Dynamic changes in left ventricular parameters under the influence of therapy with spironolactone, an aldosterone receptor blocker, are described.

[Epidemiology and risk factors of chronic renal diseases: a regional level of the problem].

Aim: Assessment of chronic renal disease (CRD) prevalence and morbidity rate and approaches to early CRD in one of the regions of the RF (Tyva Republic).

Material And Methods: A population study in the Tyva Republic performed from 01.07.

[Effect of protein load on kidney functions in patients with chronic glomerulonephritis].

Aim: To study changes in renal function in response to protein loads in patients with chronic glomerulonephritis (CGN) who have normal renal function and initial uremia.

Material And Methods: 63 CGN patients were divided into two groups: 40 patients of group 1 (17 males, 23 females, age 16-53 years, plasma creatinine-Pcr < 0.132 mmol/l); 23 patients of group 2 (10 males, 13 females, age 18-57 years, Pcr > 0.

[Effects of different variants of low-protein diet on progression of chronic renal failure and indices of nutritional status in predialysis stage].

Aim: To investigate effects of different variants of low-protein diet (LPD) (standard and with soy bean protein isolates) on inhibition of chronic renal failure (CRF) progression and prevention of protein-energy insufficiency in predialysis patients.

Materials And Methods: 150 patients with CRF were divided into three groups 50 patients each. Group 1 patients were given combined LPD with addition of soy bean isolate (0.

[The effect of urea on the course of experimental uremia in rats with a subtotal nephrectomy].

The important role of increasing plasma urea levels in renal failure progression was shown in Wistar rats with experimental uremia induced by subtotal nephrectomy. Renal structural lesions and dysfunction were the same as in rats fed a high-protein diet and in those on a low-protein diet supplemented with urea. The changes were much less in the control group of rats fed a low-protein diet alone.