The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice.

The role of the inflammasomes in aging and progeroid syndromes remain understudied. Recently, MCC950, a NLRP3 inhibitor, was used in Zmpste24 mice to ameliorate the phenotypes. However, the safety of MCC950 was questioned due to liver toxicity observed in humans.

Improved Protoplast Production Protocol for Fungal Transformations Mediated by CRISPR/Cas9 in Non-Sporulating Isolates.

is a necrotrophic fungus that causes considerable economic losses in commercial crops. Fungi of the genus exhibit great morphological and genetic variability, ranging from non-sporogenic and non-infective isolates to highly virulent sporogenic ones. There is growing interest in the different isolates in terms of their methodological applications aimed at gaining a deeper understanding of the biology of these fungal species for more efficient control of the infections they cause.

Revealing Hidden Genes in : New Insights into Genes Involved in the Biosynthesis of Secondary Metabolites.

Utilizing bioinformatics tools, this study expands our understanding of secondary metabolism in , identifying novel genes within polyketide synthase (PKS), non-ribosomal peptide synthetase (NRPS), sesquiterpene cyclase (STC), diterpene cyclase (DTC), and dimethylallyltryptophan synthase (DMATS) families. These findings enrich the genetic framework associated with 's pathogenicity and ecological adaptation, offering insights into uncharted metabolic pathways. Significantly, the discovery of previously unannotated genes provides new molecular targets for developing targeted antifungal strategies, promising to enhance crop protection and advance our understanding of fungal biochemistry.

Unravelling the Function of the Sesquiterpene Cyclase STC3 in the Lifecycle of .

The genome sequencing of supplies a general overview of the map of genes involved in secondary metabolite synthesis. genomic data reveals that this phytopathogenic fungus has seven sesquiterpene cyclase () genes that encode proteins involved in the farnesyl diphosphate cyclization. Three sesquiterpene cyclases (BcStc1, BcStc5 and BcStc7) are characterized, related to the biosynthesis of botrydial, abscisic acid and (+)-4-epi-eremophilenol, respectively.

Ultrasonication Influence on the Morphological Characteristics of Graphene Nanoplatelet Nanocomposites and Their Electrical and Electromagnetic Interference Shielding Behavior.

Graphene nanoplatelets (GNPs)/epoxy composites have been fabricated via gravity molding. The electrical and thermal properties of the composites have been studied with variable GNP type (C300, C500, and C750, whose surface areas are ~300, 500, and 750 m/g, respectively), GNP loading (5, 10, 12, and 15 wt.%), and dispersion time via ultrasonication (0, 30, 60, and 120 min).