[THE INFLUENCE OF LOCUS COERULEUS ON DIFFERENT ACTIVITIES OF THE THALAMO-CORTICAL SYSTEMS].

As revealed from our experiments, in facilitation of passage of the thalamo-cortical visual signals a key role is attributed to variability of activity of visual neurons in reticular nucleus of the thalamus. It was demonstrated that a facilitatory action of locus coeruleus gets augmented following functional exclusion of the thalamic reticular nucleus. Nevertheless, stimulation of locus coeruleus stipulated facilitation of neuronal activity in the anterior part of thalamic reticular nucleus.

Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo.

Epilepsy is one of the most widespread neurological diseases characterized by spontaneous recurrent seizures. There is no cure for epilepsy, and available pharmacological treatments with anti-seizure drugs are only symptomatic. Moreover, about third of epilepsy patients are resistant to the anti-seizure drugs.

INTERACTION BETWEEN THE THALAMIC NUCLEUS AND PREOPTIC AREA NEURONS.

The thalamic reticular nucleus which is known to delineate the dorsal thalamus stipulates development of inhibitory processes in the thalamo-cortical neurons that is necessary for generating slow (8-12 Hz), high-amplitude electric activity in this system. It was demonstrated that majority of preoptic area neurons get activated during slow-wave sleep. Activation of neurons in the anterior hypothalamus and preoptic area during slow-wave sleep and synchronization of the brain electric activity was demonstrated.

NEOCORTICAL IMPACT ON THE AUDIOGENIC SEIZURE ACTIVITY DEVELOPMENT.

Out of genetically determined epilepsy models a special interest draws the model of audiogenic seizures, which does not require whatever additional intervention (e.g. pharmacological or/and electric stimulation), because epileptic responses are elicited by specific sensory stimulation only.

[The impact of pregnancy and postnatal period on the development of generalized convulsive activity in experiment].

Interrelation between pregnancy and epilepsy is one of the pressing problems of current neurology. Those mechanisms, which suppress or amplify the seizure reactions in pregnancy, have not been yet determined experimentally. The goal of present work was investigation of impact of gestation and the postpartum period on initiation and development of convulsive reactions in the experimental animal model.